Effects of splanchnic vasoconstrictors on liver regeneration and survival after 90% rat hepatectomy

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Effects of splanchnic vasoconstrictors on liver regeneration and survival after 90% rat hepatectomy

Purpose Posthepatectomy liver failure is a serious complication and considered to be caused by increased portal pressure and flow. Splanchnic vasoactive agents and propranolol are known to decrease portal pressure. The aim of this study was to identify optimal candidates with potential for clinical use among somatostatin, terlipressin, and propranolol using rats with 90% hepatectomy. Methods ...

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Effects of protein-deprivation on the regeneration of rat liver after partial hepatectomy.

Rats maintained on a protein-free diet for 3 days have an altered time course of hepatic DNA synthesis during liver regeneration. The delay in DNA synthesis is eliminated by the administration of casein hydrolysate (given as late as 6h after partial hepatectomy), but not by glucose or incomplete amino acid mixtures. Despite the change in the timing of DNA synthesis, the increases in hepatic ami...

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Regeneration of mouse liver after partial hepatectomy.

The rapidly growing liver tissue after partial hepatectomy has been used advantageously by in vestigators to study changes during accelerated growth and proliferation of cells (4, 7, 12, 15). Previous reports have been chiefly on rats. In many instances, pooled samples were taken for chemical data. In the present investigation a com prehensive study was made on individual samples of regeneratin...

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Silymarin Accelerates Liver Regeneration after Partial Hepatectomy

Partial hepatectomy (PHx) is a liver regeneration physiological response induced to maintain homeostasis. Liver regeneration evolved presumably to protect wild animals from catastrophic liver loss caused by toxins or tissue injury. Silymarin (Sm) ability to stimulate liver regeneration has been an object of curiosity for many years. Silymarin has been investigated for use as an antioxidant and ...

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Gene expression of ATP-binding cassette transporters during liver regeneration after 90% hepatectomy in rats.

Liver damage with hyperbilirubinemia during regeneration of the small liver is the major hurdle to expand the indications of adult living donor liver transplantation. We performed a large-scale gene expression analysis of the regenerating liver after a 90% hepatectomy in rats, and analyzed the changes in the gene expression patterns related to the ATP-binding cassette (ABC) transporters. RNAs w...

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ژورنال

عنوان ژورنال: Annals of Surgical Treatment and Research

سال: 2018

ISSN: 2288-6575,2288-6796

DOI: 10.4174/astr.2018.94.3.118